Jean‐Luc Wolfender is Professor at the University of Geneva where he leads the phytochemistry bioactive natural product (PBNP) group. Since the 1990s, he has helped introduce LC-MS and LC-NMR for the profiling of natural extracts for dereplication and to accelerate the discovery of novel bioactive compounds. He is currently developing innovative metabolomic approaches based on mass spectrometry (MS) and nuclear magnetic resonance (NMR) in various aspects of natural product research and includes LC-MS computational approaches for data mining with a focus on generic assessment of natural extracts composition. His research focuses on discovering NP-based drugs and evidence-based phytotherapy and also covers the search for new NP that can be induced in response to stimuli.