DEVELOPMENT OF SKINCARE FORMULATION FROM A MALPIGHIACEAE PLANT WITH ANTI-AGING PROPERTIES
- Group:Abstracts
DEVELOPMENT OF SKINCARE FORMULATION FROM A MALPIGHIACEAE PLANT WITH ANTI-AGING PROPERTIES
Lorena Ramos Freitas de Sousa
lorennarf@ufcat.edu.br
Laboratório de Bioquímica e Química Orgânica (LaBiOrg), Instituto de Química, IQ, UFCAT, Av. Dr. Lamartine Pinto de Avelar, 1120 Setor Universitário, CEP: 75704-020, Catalão, Goiás, Brazil.
The topical application of antioxidant agents combined with enzyme inhibitors in cosmetic formulations helps reduce hyperpigmentation and delay skin aging. Elastase and tyrosinase are key enzymes targeted in the development of active ingredients with anti-aging and skin-brightening properties.[1,2] Natural products (NPs) are widely used in cosmetics, and many of their secondary metabolites have demonstrated notable enzyme-inhibitory potential.[1-3] We have been investigating the sustainable use of active ingredients derived from plants collected in the Cerrado biome for the development of phytocosmetic formulations.[4] One species belonging to the Malpighiaceae family has shown anti-elastase potential and low cytotoxicity. An active extract obtained from its leaves was incorporated into cosmetic formulations such as a cream and facial gel at BIOCAP company. Accelerated stability tests revealed that the extract remains promising when incorporated into cosmetic formulations.
Keywords: Malpighiaceae, skincare formulation, elastase
References: [1] Calleja-Agius, J.; BRINCAT, M.; BORG, M. Skin connective tissue and ageing. Best. Pract. Res. Clin. Obstet. Gynaecol. 27: 727-740, 2013.
[2] Korkmaz, B., Horwitz, M.S., Jenne, D.E., Gauthier, F.. Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol. Rev. 62: 726–759, 2010.
[3] Chiocchio, I., Mandrone, M., Sanna, C., Maxia, A., Tacchini, M., & Poli, F. Screening of a hundred plant extracts as tyrosinase and elastase inhibitors, two enzymatic targets of cosmetic interest. Industrial Crops and Products 122: 498–505, 2018.
[4] da Silva CF, Wihelms RZ, Queiroz Júnior LHK, dos Santos NCF, de Oliveira AE, Lopes PS, Costa LS, Severino MR, de Sousa LRF, Macedo APMG, Severino VGP. Chemical profiling and cosmeceutical potential of Hymenaea stigonocarpa fruit peel and seeds, Food Chemistry 493: 145961, 2025.
Acknowledgements: BIOCAP,National Council for Scientific and Technological Development (CNPq) (Process 403611/2020-2, MAI/DAI Program at UFCAT), Goiás State Research Support Foundation (FAPEG, 202310267001406) and FUNAPE.
